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Piperine has been found to inhibit human CYP3A4 and P-glycoprotein,enzymes important for the metabolism and transport of xenobiotics and metabolites.
In animal studies, piperine also inhibited other enzymes important in drug metabolism By inhibiting drug metabolism, piperine may increase the bioavailability of various compounds and alter the effectiveness of some medications.
Notably, piperine may enhance bioavailability of curcumin by 2000% in humans The exact mechanism of piperine's bioavailability enhancing abilities is unknown.
Chemopreventive efficacy of curcumin and piperine has been shown during 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis.
Recently the journal Molecular Nutrition Food Research published evidence that piperine can enhance the pharmacokinetic parameters of resveratrol via inhibiting its glucuronidation, thereby slowing its elimination.

In February 2008, researchers discovered that piperine can stimulate pigmentation in the skin, together with the exposure to UVB light

Piperine has shown 'anti-depression like activity', and cognitive enhancing effects in rats

Piperine has shown anti-inflammatory and anti-arthritic effects in human interleukin-1beta-stimulated fibroblast-like synoviocytes and in rat arthritis models


A bit technical, but it explains how piperine works in a chemical way. I have also included links that explains some of the big words.


Piperine is found in black pepper, so by including black pepper in your diet you can enhance other spices that you use.
Piperine has its own anti-inflammatory properties so when used with Turmeric they complement and enhance each other